What is MUSE (medicated urethral suppository for erection)?
MUSE is short for "medicated urethral system for erection." This treatment is based on the discovery that the urethra (the tube passing from the bladder to the tip of the penis through which urine is passed and semen ejaculated) can absorb certain medications, which can then pass into the surrounding erectile tissue creating an erection.
The active ingredient in MUSE is alprostadil. This is identical to a naturally occurring substance within the penis which is involved in the development of an erection. Alprostadil has been used in the treatment of impotence for many years. Before the introduction of MUSE it had to be injected into the penis when an erection was wanted. Alprostadil relaxes the muscles in the erectile tissue of the penis allowing increased blood flow, the basis of a normal erection. In MUSE, alprostadil is formulated as a small pellet which is supplied in a specially designed applicator. Each MUSE applicator is individually foil wrapped. The applicator has a narrow stem which can be introduced easily into the urethra. After inserting the applicator, the alprostadil pellet is then released into the urethra by depressing a button on the top of the applicator. The manufacturer recommends that immediately prior to insertion of MUSE, the man urinates and then gently shakes the penis several times to remove excess urine. A moist urethra makes administration of MUSE easier and facilitates the absorption of alprostadil.
Physicians will commonly have a patient try a suppository in the office to determine appropriate dosage. Before using urethral suppositories, the man urinates. This helps to insure the moist surfaces that help the medication to be absorbed. With a small applicator, the man inserts a pellet of medication into his urethra, the small hole on the tip of the penis. He then massages his penis for about a minute to help the pellet dissolve. To help speed absorption, he should also remain upright for several minutes. He may also place a small rubber band around the base of his penis before inserting the suppository. This can help hold the medication in his penis.
A man generally will get an erection within 10-15 minutes of application. The erection will last about 30-60 minutes. When this form of treatment is effective, an erection generally lasts 30 to 60 minutes. Extremely rarely a prolonged erection may occur. MUSE can be used twice in any 24 hour period, however 2 units should not be used consecutively.
Different doses: MUSE is available in four strengths - 125 mcg, 250 mcg, 500 mcg and 1,000 mcg. The initial dose is selected by the doctor.
Side effects have been reported only infrequently. When first using MUSE, some men experience minor discomfort from insertion but prior urination will reduce the chance of this happening. Following the first dose of MUSE, fainting has occurred, but only in an extremely small proportion of men. However, for this reason, it is recommended that the first dose of MUSE should be in the doctor's office. Other side effects that have been reported, albeit extremely rarely, include light-headedness, dizziness, fainting, rapid pulse and swelling of the leg veins. Patients are advised not to drive up to one hour after using MUSE.
More information on impotence (erectile dysfunction)
What is impotence or erectile dysfunction? - Impotence is the inability of the male to have an erection. Some men may become impotent after having diabetes for a long time because the nerves or blood vessels have become damaged. Impotence may have a physiological or psychological basis.
How does erection occur? - Erection begins with sensory and mental stimulation. Impulses from the brain and local nerves cause the muscles of the corpora cavernosa to relax, allowing blood to flow in and fill the open spaces.
What causes impotence? - A common cause of impotence is a high level of atherosclerosis in the arteries feeding the penis. Damage to arteries, smooth muscles, and fibrous tissues, often as a result of disease, is the most common cause of impotence.
What are the physical causes of impotence? - Physical impotence occurs when there is a problem with any of the systems needed to get or maintain an erection. Hardening of the arteries can affect the artery leading to the penis so that it cannot dilate enough to deliver all the blood necessary for an erection.
What are the psychological causes of impotence? - Psychological causes of impotence often include work pressures, financial worries, fear of aging, or frustration with relationships. Depression and anxiety disorders are cited as the most common causes of psychological impotence.
How is impotence (erectile dysfunction) treated? - Treatment depends on the cause. Testosterone supplements may be used for cases with hormonal deficiency. Drugs for treating impotence can be taken orally or injected directly into the penis.
What're non-prescription treatments for impotence? - Among the herbs used for erectile dysfunction are yohimbine, gingko biloba (to increase blood flow), ginseng, pygeum, and muira puama. A penile sheath is a rigid or semi-rigid support put over the penis to support it for intercourse.
What is MUSE? - MUSE is short for "medicated urethral system for erection." This treatment is based on the discovery that the urethra can absorb certain medications, which can then pass into the surrounding erectile tissue creating an erection.
What is Viagra (sildenafil citrate)? - Viagra (sildenafil citrate), a prescription medication for the treatment of erectile dysfunction, is the first pill available that's been proven to improve erections in most men with impotence.
What is Levitra (vardenafil)? - Levitra (vardenafil HCl) is a PDE inhibitor drug. This medication helps improve erection during sexual arousal and activity but erection should end after sexual activity is complete.
What is Cialis (tadalafil)? - Tadalafil (Cialis?) is a drug used to treat male erectile dysfunction (impotence). The generic name for this compound is tadalafil.
What about penile injection therapy? - Penile injection therapy is non surgical technique used to treat impotence. Penile injections have the advantage of not involving surgery. They are also effective in many dialysis patients.
What are penile implants for impotence? - Penile implants (often called "internal penile pumps") are one of several erectile dysfunction treatment options. The inflatable penile prosthesis is a pump system surgically placed in the penis.
What is hormonal therapy for impotence? - Sexual desire (libido) and an overall sense of well-being are likely to improve when serum testosterone levels (the level of the male hormone in the blood) are restored.